Shoc2 uniprot

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August undefined, 2024

Web15 Apr 2024 · The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the … WebSHOC2 localizes to cytoplasm when inactive but rapidly translocates to the nucleus when activated, such as during growth factor stimulation. Thus, as expected, SHOC2 also participates in FGF receptor signaling. ... Uniprot describes 2 isoforms at ~60 kDa and ~65 kDa Uncharacterized bands may appear in some lysate(s). Physical form.

UniProt

WebQ9UQ13 - SHOC2 - Leucine-rich repeat protein SHOC-2 - Medical. Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at … WebMolecularly, SHOC2 is a scaffold protein that brings together activated Ras (activated via G-protein coupled receptors and the interaction of GTP to GDP) and Raf, which then facilitates the transfer of the phospho-Raf phosphate to other proteins for the activation of the MAP Kinase pathway for gene activation. dj leska vay mp3

Structure of the SHOC2–MRAS–PP1C complex provides ... - bioRxiv

WebResearch studies have demonstrated that SHOC2 forms a complex with the catalytic subunit of the PP1 phosphatase and M-Ras, and this complex drives activation of Raf-ERK signaling in response to mitogenic growth factors (1). SHOC2 has also been shown to cross-talk with and activate the PI3K/Akt signaling axis through its interaction with the ... Web29 Sep 2024 · SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS 11-13 , but the structure of SHOC2 and the … WebUniProt accession no. Q9UQ13. shipped in. dry ice. storage temp. −20°C. Gene Information. human ... SHOC2(8036) ... SHOC2, together with protein phosphatase 1c (PP1c), forms a highly specific M-Ras effector complex and is essential for the activation of MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations ... dj leska vrai nom

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Shoc2 uniprot

To investigate the genetic basis in RASopathy patients TACG

WebSHOC2 gene product. KIAA0862, SOC-2, SOC2, SUR-8, SUR8 . This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene ... Web13 Jul 2024 · A structure of the MRAS–SHOC2–PP1C complex supports a RAS-driven and multi-molecular model for RAF activation in which individual RAS–GTP molecules recruit RAF–14-3-3 and SHOC2–PP1C to ...

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Web29 Sep 2024 · SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS 11-13 , but the structure of SHOC2 and the … Web13 Jul 2024 · SHOC2 forms a ternary complex with MRAS and PP1C, and human germline gain-of-function mutations in this complex result in congenital RASopathy syndromes 2, 3, 4, 5. However, the structure and...

UniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2024. See more This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. 1. Name1 2. See … See more Web14 Dec 2024 · The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the …

WebSHOC2-003: 815: No protein- Gene/transcript that doesn't contain an open reading frame (ORF). Processed transcript---ENST00000489783.1: SHOC2-004: 749: ... Uniprot. This transcript corresponds to the following Uniprot identifiers: Q9UQ13. CCDS. This transcript is a member of the Human CCDS set: CCDS7568. Version. ENST00000369452.4.

WebWelcome to ProteomicsDB! ProteomicsDB is an effort of the Technische Universität München (TUM). It is dedicated to expedite the identification of the human proteome and its use across the scientific community. dj liborWebSHOC2 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, SHOC2 Genome Browser, SHOC2 References. ... UniProt Q9UQ13 Pfam Q9UQ13 Atlas Genetic Oncology n/a HGNC 15454. Drug resistance. This section shows the drugs associated with SHOC2 resistance mutations. In the tabs below you can see any other genes that have ... dj liberoWebSHOC2 leucine-rich repeat scaffold protein (HGNC Symbol) Entrez gene summary. ... Q9UQ13 (UniProt - Evidence at protein level) neXtProt. NX_Q9UQ13: Antibodypedia. SHOC2 antibodies: PROTEIN BROWSER. SHOC2-001. SHOC2-002. SHOC2-201. PROTEIN INFORMATION. Splice variant. UniProt. Protein class. Gene ontology. dj lhbWebSHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. dj libramontWebRegulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. This gene encodes a protein that consists … dj liam saWebNX_Q9UQ13 - SHOC2 - Leucine-rich repeat protein SHOC-2 - Structures. Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at … dj levi chinWebAll lanes : Anti-Shoc2 / Sur8 antibody (ab229805) at 1/500 dilution Lane 1 : MCF7 (human breast adenocarcinoma cell line) whole cell lysate Lane 2 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate Lane 3 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate Secondary All lanes : Goat polyclonal to rabbit IgG at … dj libro mantova