Phenogroups
WebFive distinct phenogroups were identified, three younger groups (group 1–3) and two older groups (group 4–5): group 1, least comorbidities; group 2, men with LV enlargement; group 3, predominantly women with rheumatic MR; group 4, low-risk older patients; and group 5, high-risk older patients. Phenogroup 3 (n = 899) demonstrated more functional impairment, obesity, diabetes, chronic kidney disease, concentric LV hypertrophy, high renin, and biomarkers of tumor necrosis factor-alpha–mediated inflammation, liver fibrosis, and tissue remodeling.
Phenogroups
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WebMay 10, 2024 · In a recent study, distinct phenogroups were detected in patients referred for symptoms of heart failure (HF) but not yet identified as HF. These phenogroups, along …
WebApr 12, 2024 · Kao et al. reported phenogroups with a high rate of atherosclerotic factors, such as coronary artery disease, DM, and CKD, in patients enrolled in the I-Preserved trial, and these phenogroups with a high risk of atherosclerosis showed the worst outcome. 9 Cohen et al. proposed that the phenogroup with high-risk factors for atherosclerosis and ... WebMay 1, 2024 · Phenogroups also stratified risk of the secondary composite outcome at 6 and 12 months more effectively than LVEF. Conclusion: Among patients hospitalized for HF, clinical phenotypes generated by ...
WebMar 1, 2024 · Phenogroup 3 (n = 899) demonstrated more functional impairment, obesity, diabetes, chronic kidney disease, concentric LV hypertrophy, high renin, and biomarkers of tumor necrosis factor-alpha-mediated inflammation, liver fibrosis, and tissue remodeling. WebApr 12, 2024 · PDF Aims: Heart failure (HF) with preserved ejection fraction (HFpEF) is a complex syndrome with a poor prognosis. Phenotyping is required to... Find, read and cite all the research you need ...
WebMar 8, 2024 · Phenogroup 3: Oldest, more likely to have chronic kidney disease with highest serum creatinine and lowest glomerular filtration rate (GFR), highest BNP (B-type …
WebJan 15, 2024 · In men and women separately, 4 distinct phenogroups were identified on the basis of Akaike's Information Criterion, Bayesian Information Criterion, and visual inspection. The 4 phenogroups were described as (1) ideal cardiac mechanics; (2) higher output/hypertrophied LV; (3) impaired EF/dilated LV; and (4) higher output/hyperdynamic … lighting stores yonkers nyWebJan 2, 2024 · Furthermore, our analysis indicates that heterogeneous diseases, like dilated cardiomyopathy, could be classified into two phenogroups with distinct clinical characteristics. Finally, AIEchoDx... lighting stores york paWebSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources peake restorationWebPhenogroups with a higher incidence of atherosclerotic risk factors have also been identified in previous reports. Kao et al. reported phenogroups with a high rate of atheroscle-rotic factors, such as coronary artery disease, DM, and CKD, in patients enrolled in the I-Preserved trial, and these phenogroups with a high risk of atherosclerosis ... lighting strike clip artWebMar 8, 2024 · Phenogroups in heart failure with preserved ejection fraction Clustering analysis of heart failure with preserved ejection fraction (HFpEF) has been used to define three distinct phenogroups by Shah SJ et al [1]. They used dense phenotypic data for “phenomapping”. lighting strandsWebOct 14, 2024 · The derived phenogroups correspond with established risk profiles in HCM. An expanded dataset is needed to enable further exploration of the phenotype-genotype relations and to define prognostic value. Funding Acknowledgement. Type of funding sources: Public grant(s) – EU funding. Main funding source(s): This work was supported … lighting strike love italianWebAt the primary endpoint, Phenogroup 1 demonstrated the worst prognosis (Phenogroups 1-3: 72.0% vs. 58.5% vs. 45%, P = 0.0036). We also successfully classified a derivation cohort into three similar phenogroups using VBGMM. Hierarchical and supervised clustering successfully showed the reproducibility of the three phenogroups. lighting strategy city of london