WebNov 25, 2010 · Microarray analysis revealed that CRELD2 and ALG12 mRNAs were induced in Neuro2a cells by treatment with thapsigargin (Tg), an ER stress inducer, in a time-dependent manner. Other ER stress inducers, tunicamycin and brefeldin A, also increased the expression of these two mRNAs in Neuro2a cells. WebDec 7, 2024 · Thus, there is an urgent need to develop ER stress biomarkers in the incipient stages of ER stress–mediated kidney disease, when a kidney biopsy is not yet clinically indicated, for early therapeutic intervention. Cysteine-rich with EGF-like domains 2 (CRELD2) is a newly identified protein that is induced and secreted under ER stress.
Creld2 function during unfolded protein response is essential fo…
WebJun 30, 2011 · We previously demonstrated that CRELD2 is a novel ER stress-inducible gene [ 11], which is transcriptionally regulated by ATF6 (one of the three major ER stress sensors, ATF6 [ 7 - 10], PERK [ 5, 8] and IRE1 [ 6, 9] ), but its molecular features and functions are hardly characterized. WebAug 11, 2024 · CRELD2 as a urine ER stress biomarker in both mouse models and human diseases CRELD2 was first identified as a novel ER stress-inducible gene through RNA analysis of Neuro2a mouse neuroblastoma cells treated with thapsigargin, which depletes ER calcium through inhibition of ER calcium uptake by ER calcium ATPase [ 52 ]. daylily for shade
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WebElevated urinary CRELD2 is associated with endoplasmic reticulum stress–mediated kidney disease Yeawon Kim, Sun Ji Park, Scott R. Manson, Carlos A.F. Molina, Kendrah Kidd, Heather Thiessen-Philbrook, Rebecca J. Perry, Helen Liapis, Stanislav Kmoch, Chirag R. Parikh, Anthony J. Bleyer, Ying Maggie Chen WebNov 21, 2024 · Oxidative stress in the epididymal microenvironment induces ER stress in the EECs. This effect alters the epididymis-derived exosome content, profile and amounts of their differentially expressed … WebAug 16, 2024 · CRELD2 is an ER-stress regulated gene that has been implicated in the pathogenesis of skeletal dysplasias and has been shown to play an important role in the … gawain hightower